Mechanism of Action

What is the history of NeuroAiD™?

NeuroAiD™ (MLC 601) originated in traditional Chinese medicine (TCM) and is meant to help stroke patients achieve better rehabilitation after stroke onsetIt is not surprising that the answer to stroke, a complex disease, comes from a natural treatment. Natural treatments have been the origin of many drugs (aspirin, Taxol for cancer…), and it is likely that NeuroAiD™ acts in a multimodal manner on several of the mechanisms involved in stroke recovery.

Moleac, a biopharmaceutical company based in Singapore and with offices in France, has identified NeuroAiD™ and its potential to meet the needs of stroke survivors. Moleac ensures that NeuroAiD™ meets the stringent standards of mainstream medicine and is bringing NeuroAiD™ to neurologists, neurosurgeons, and their patients to attend to their needs after a stroke and to support them to achieve better neurological and functional recovery.

How does your brain work?

Neurological functions

A human brain has approximately 100 billion neurons. The neuronal circuit consists of about 100 trillion connections between these neurons (made of dendrites and synapses), which centrally command all our neurological functions and, mediated by our nerves, allow us to move, think, speak, and interact socially. The brain remains a highly dynamic structure that adapts neuronal circuitry to each event of life. For example, when one learns a new skill, some connections are wired in the brain.

Consequences of a stroke

Brain neurons are hungry for oxygen and glucose, which are supplied by blood vessels in the brain. While the brain represents a mere 5% of the body’s weight, neurons consume 20% of the body’s total consumption of oxygen and nutrients.

A stroke occurs when the blood supply in an area of the brain is interrupted due to a clot in a vessel (ischemia) or as a consequence of bleeding (hemorrhage). Deprived from oxygen and glucose, the neurons located in the damaged area die within minutes. The consequence is a disruption of information processing and transmission through the nervous system at the location of the stroke. This creates a number of physical impairments, which can include hemiplegia, aphasia, or cognitive deficits.

A stroke is an emergency. In some cases, if the patient reaches the hospital in the first hours following an ischemic stroke and qualifies for a treatment called thrombolysis, some of the neuronal tissues may be saved and thus limit the disabilities resulting from a stroke.

Recovery after a stroke

Our brain has some natural ability to recover by rewiring itself, through its capacity to reorganize healthy neurons to form new information circuits. When this happens in the brain, this process is called neuroplasticity, and after a stroke, it can be stimulated by rehabilitation therapy. One of the key drivers of the success of any rehabilitation program is carefully directed, well-focused, repetitive practice—the same kind of practice used by all people when they learn a new skill, such as playing the piano.

How NeuroAiD™ supports recovery?

NeuroAiD™ creates a favorable environment to enhance neuroplasticity.

Precisely, NeuroAiD™ triggers the production of new neurons in our brain (neurogenesis) and favors connections between neurons by stimulating the formation of dendrites and synapses (neuroplasticity).

This favors the formation of new functional neuronal circuits, which are key to a fuller post-stroke recovery. The changes in the brain materialize into more progress in neurological functions during rehabilitation. This neurorehabilitative activity of NeuroAiD™ was established in 2010 by a team of French scientists and published in peer reviewed international journal.