DETAILED CLINICAL DATA

 

This section presents detailed clinical data available on Neuroaid: the results displayed are the results of a meta-analysis of all existing clinical trials performed to date on Neuroaid

 

Functional outcome defines the level of independence of the patient after a stroke and during the recovery. As such the scales commonly used by the doctors to assess the level used are modified Rankin scale (mRS) or the Barthel Index to assess the patient’s independence to do the daily activities.

 

Clinical trial on NeuroAiD™ on 605 patients showed that patient on NeuroAiD™ had 2.11 times more chance to reach independence. The below plot shows that patients on NeuroAiD™ had a significantly better chance of leading an independent life than those of the control group*.

 


* Not receiving NeuroAiD™

 

 

NEUROLOGICAL DEFICIT RESEARCH

 

 

Upper Limb Paralysis

Limb paralysis is the most common symptom post stroke.  The side of the body affected is opposite to the part of the brain affected by stroke. The functions affected can be loss of gross or fine motor functions.  There is an associated loss of sensory impairment, which can cause the patient to suffer from pain, burning, sensation of nombness. The patient might not become aware of as he does not feel the pain. The other symptoms can be numbness or tingling.

 

Here below are the results of these clinical trials enrolling 605 patients, 400 receiving NeuroAiD™ and 205 a control medicine:

 



The upper limb motor improvement was significant for patients receiving NeuroAiD™. The results are statistically significant (p=0.006)



The plot on finger paralysis (Fig.2) improvement also shows it to be slightly favorable to NeuroAiD™. The first study was clearly positive, although the second one neutral to slightly positive, the overall being not statistically significant.

 

 

 

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Lower Limb Paralysis



The lower limb motor improvement was significant for patients receiving NeuroAiD™. The results are indeed statistically significant (p=0.0001)


The above figure 1 and 2 shows that NeuroAiD™ significantly helps in improving lower limb paralysis as well as toe paralysis respectively in post stroke patients. These results are statistically significant (p=0.02).

 

 

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Facial Paralysis

A number of patients have facial paralysis following their stroke, which could be due to the involvement of the facial nerve itself (complete paralysis) or the motor area of the brain supplied by the nerve (partial paralysis). A few of the signs and symptoms of the patients suffering from facial paralysis are:

  • asymmetrical smile, tearing or dry eye, inability to close eye, abnormal blink, inability to whistle or pucker lips,
  • buccinator paralysis (food caught in cheek of paralyzed side), inability to "puff" one's cheeks, drooling of liquids from corner of paralyzed mouth,
  • hyperacussis (perceiving sounds as unduly loud),excessive perspiration, weakened facial musculature,
  • lack of wrinkling on forehead of paralyzed side, change in taste (sensory part of the nerve involved), changes in speech, tightness / swelling of facial muscle.

The plot below details the results of the clinical trial on 605 patients. The first study was clearly positive on the effect of NeuroAiD™ on facial paralysis, the 2nd study slightly positive but not statistically significant. On average, NeuroAiD™ seems to help victims of facial paralysis.

 

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Speech Problems and Motor Function


A person who has suffered stroke may experience the following speech problems-
Aphasia is a condition that can affect all language areas including speaking, understanding, reading, and writing in varying degrees

The following suggestions may be helpful: Ask questions that call for a yes or no answer, Speak in short phrases, Talk about familiar topics or people, Give the person time to think of words.

Apraxia is a motor planning problem which affects the ability to formulate the sounds of speech.

The following suggestions may be helpful in: Ask the person to slow down and say each word carefully, avoid interrupting the person, encourage the use of gestures, encourage any vocalization such as singing familiar songs.

Dysarthria is a weakness or paralysis of the muscles used for speech and results in a person's speech being slurred and difficult to understand.

The following suggestions may be helpful: Ask the person to speak slowly and overemphasize the words, encourage the person to open his mouth, Let the person know when you don't understand and ask him to repeat.

 

 

Post-Stroke Rehabilitation Fact Sheet mentioning the post stroke deficits, importance of rehabilitation, types of rehabilitation etc can be viewed at http://www.ninds.nih.gov/disorders/stroke/poststrokerehab.htm

 

 

 

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